Contact

Abdulla.mamun@pwr.edu.pl 
L-1, room 28
Google Scholar 

Research

I specialize in developing peptide-based chemical tools to monitor protease activity with high precision. My current work focuses on creating a multiplexed system using smart metal-tagged probes that become activated only in the presence of specific active enzymes, such as metalloproteinases (MMPs) and ADAM family proteases. This approach enables functional detection of protease activity at the single-cell level using mass cytometry.

I collaborate with Prof. Boris Turk at the Jožef Stefan Institute in Slovenia to design MRI-compatible metal probes for imaging cathepsin activity. These next-generation agents significantly outperform traditional contrast agents like Magnevist and have been validated in phantom imaging models.

At Jagiellonian University in Poland, I work with Dr. Tomasz Kantyka on synthesizing selective inhibitors and fluorescent probes for PAD2 and PAD4. These tools are used to study enzyme activity in live cells and support our broader interest in inflammatory signaling and enzyme regulation

Education and research internships

2022 - Present, Ph.D. Candidate- Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Faculty of Chemistry, Department of Chemical Biology and Bioimaging, Wrocław, Poland.

2017-2020 M. Sc in Chemical Engineering, Nanjing University of Science & Technology, Nanjing, China.

Publications

Horbach N, Kalinka M, Ćwilichowska-Puślecka N, Mamun AA, Mikołajczyk-Martinez A, Turk B, Snipas SJ, Kasperkiewicz P, Groborz KM, Poręba M. Visualization of calpain-1 activation during cell death and its role in GSDMD cleavage using chemical probes. Cell Chemical Biology Apr 17 (2025) doi: 10.1016/j.chembiol.2025.03.002.

Islam R, Parves MR, Paul AS, Mamun AA, Hossain MN, Ali MA, Halim MA. A molecular modeling approach to identify effective antiviral phytochemicals against the main protease of SARS-CoV-2. Journal of Biomolecular Structure and Dynamics May 12 (2020) doi:10.1080/07391102.2020.1761883.

Mamun AA, Zheng M, Ling Q, Ju XH. Theoretical investigation on the QSAR of (2-methyl-3-biphenylyl) methanol (MBPM) analogs as PD-L1 inhibitor. Chinese Journal of Chemical Physics Aug 27 (2019) doi:10.1063/1674-0068/cjcp1909168.

Chowdhury SM, Talukder SA, Khan AM, Mamun AA, Sufian MA, Hossain MN, Hossain A, Halim MA. Antiviral peptide as promising therapeutics against SARS-CoV-2. The Journal of Physical Chemistry Part: Part B Nov 5 (2020) doi:10.1021/acs.jpcb.0c05621.

Rahman MM, Saha T, Mamun AA, Khan M, Ali MA, Halim MA. Virtual screening, molecular dynamics and structure–activity relationship studies to identify potent approved drugs for COVID-19 treatment. Journal of Biomolecular Structure and Dynamics June 21 (2020) doi:10.1080/07391102.2020.1794974.

Mamun AA, Akter F, Khan M, Ahmed SS, Uddin MG, Tasfia NT, Efaz FM, Ali MA, Sultana MUC, Halim MA. Identification of potent inhibitors against transmembrane serine protease 2 for developing therapeutics against SARS-CoV-2. Journal of Biomolecular Structure and Dynamics  Sep 30(2021)  doi:10.1080/07391102.2021.1980109.

Ahmed S, Mahtarin R, Mamun AA, Ahmed SS, Islam R, Islam S, Aktar S, Hossain MN, Sultana MUC, Ali MA, Halim MA. Investigating the binding affinity, interaction, and structure-activity-relationship of 76 prescription antiviral drugs targeting RdRp and Mpro of SARS-CoV-2. Journal of Biomolecular Structure and Dynamics. Jul 28 (2020) doi:10.1080/07391102.2020.1796804.

Paul AS, Islam R, Parves MR, Mamun AA, Hossain ISMN, Ali MA, Halim MA. Cystine focused inhibitors against the main protease of SARS-CoV-2. Journal of Biomolecular Structure and Dynamics Oct 13 (2020) doi:10.1080/07391102.2020.1831610.

Ahmed S, Mahtarin R, Islam MS, Das S, Mamun AA, Ahmed SS, Ali MA. Remdesivir analogs against SARS-CoV-2 RNA-dependent RNA polymerase. Journal of Biomolecular Structure and Dynamics Jul 27 (2021) doi:10.1080/07391102.2021.1955743.

Conferences

Mamun AA, Majchrzak M, Ćwilichowska-Puślecka N, Poręba M. Activatable cell-penetrating peptide probes for visualizing MMPs and ADAMs activity in breast cancer cells: a multimodal approach. Presented at: Gordon Research Conference on Proteolytic Enzymes and Their Inhibitors, Renaissance Tuscany Il Ciocco in Lucca (Barga), Lucca, Italy. 6/2024.

Mamun AA, Poręba M. Development of PAD2 and PAD4 inhibitors for rheumatoid arthritis (RA) therapy. Gordon Research Seminar on Proteolytic Enzymes and Their Inhibitors, Renaissance Tuscany Il Ciocco, Lucca, Italy. 6/2024.

Mamun AA, Poręba M. Design and synthesis of novel PAD-2/4 inhibitors: precision targeting for rheumatoid arthritis (RA) treatment. 26th Polish Peptide Symposium, Stare Jabłonki, Poland. 9/2023