Contact

magdalena.wadrzyk@pwr.edu.pl
L-1, room 28
LinkedIn

Research

My research focuses on studying the heterogeneity of neutrophils – one the most abundant cells of the immune system – under pathological conditions. The main goal is to define the subpopulations of these cells based on the presence of surface receptors and the level of expression and activity of neutrophil serine proteases (NSPs), which perform key effector functions. To assess the enzymatic activity of NSPs, I apply new, previously unused chemical probes developed in our team. Flow cytometry analyzes allowed the identification of new neutrophil populations, which provides valuable information on their phenotypic diversity, which may translate into functional heterogeneity in the course of diseases.

Education

2021-currently PhD in Chemical Biology and Bioimaging, Wroclaw University of Science and Technology, Department of Chemistry, Neutrophil Heterogeneity Based on Serine Proteases in diseases.

2020-2021 MSc in Pharmaceutical Biotechnology, Wroclaw University of Science and Technology, Poland, Desing and Synthesis of Substrate Quenched Activity - Based Probe for Neutrophil Serine Protease 4.

Projects

02-30.09.2021, 1.08-29.12.2023 Fix Neutropenia (FIXNET): focusing on neutrophil proteases defects which serve as novel diagnostic and therapeutic options,  POIR.04.04.00-00-1603, TEAM-NET, FNP (contractor)

01.10.2021- 30.07.2023, 01.01.2024 – currently, Heterogeniczność neutrofilii zależna od proteaz serynowych, 2020/38/E/NZ3/00507, SONATA BIS, NCN (contractor)

Publications and Awards

Wądrzyk M., Miśkiewicz J., Kasperkiewicz P., Peptydowe związki makrocykliczne: nowe perspektywy w diagnostyce i terapii chorób, Wiadomości Chemiczne, 78,11-12, 2024.

Siomra Agnieszka, Wawrzyńczyk Dominika, Cichy Bartlomiej, Wadrzyk Magdalena, Kasperkiewicz Paulina, Samoć Marek, Nyk Marcin, Efficient quenching of two-photon absorption induced photoluminescence in carbon nanodots for Fe3+ ions detection, ACS Omega, 10, 26, 2025.

Heck-Sloane Fellowship Award Winner – 2024 – Gordon Research Conference

Conferences

Magdalena Wądrzyk, Paulina Kasperkiewicz, Quenched fluorescent substrate-based probe for detection of neutrophils cathepsin G, MedChem2023, XII Meeting of the Paul Ehrlich Euro-PhD Network, 16-18.06.2023, Saloniki, Grecja. (poster)

Magdalena Wądrzyk, Kornelia Steindel, Lauren Eyssen, Wojciech Młynarski, Marcin Drąg, Paulina Kasperkiewicz, Badanie aktywności neutrofilowych proteaz serynowych w neutropeniach z wykorzystaniem inhibitorowych sond chemicznych, 65. Zjazd Polskiego Towarzystwa Chemicznego, PTChem 2023, 18-22.09.2023, Toruń, Polska. (poster)

Wądrzyk Magdalena, Steindel Kornelia, Salvesen Guy, Kasperkiewicz Paulina, „Neutrophil heterogeneity based on expression and activity of neutrophil serine proteases in disease”, Proteolytic Enzymes and Their Inhibitors, Gordon Research Conference, 09-14.06.2024, Włochy. (poster)

Wądrzyk Magdalena, Steindel Kornelia, Guy Salvesen, Kasperkiewicz Paulina, Neutrophil heterogeneity based on expression and activity of neutrophil serine proteases in disease, Proteolytic Enzymes and Their Inhibitors, Gordon Research Seminar, 08-09.06.2024, Włochy. (prezentacja ustna)

Wądrzyk Magdalena, Steindel Kornelia, Salvesen Guy, Kasperkiewicz Paulina, Heterogeniczność neutrofili na podstawie ekspresji i aktywności proteaz serynowych, 66. Zjazd Polskiego Towarzystwa Chemicznego, 16-18.10.2024, Poznań, Polska. (prezentacja ustna)

Magdalena Wądrzyk, Kornelia Steindel, Danuta Bryzek, Joanna Kozieł, Guy Salvesen, Paulina Kasperkiewicz, Neutrophil subsets based on amount and the activity of neutrophil serine proteases, 42nd Winter School  on  Proteinases and Their Inhibitors , 12-16.03.2025, Tires, Włochy. (prezentacja ustna).