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Contact
julia.miskiewicz@pwr.edu.pl
L-1, room 32
LinkedIn
Research
My research concerns the development and synthesis of a combinatorial library of macrocyclic peptides with unnatural amino acids. The library will be used in screening of catalytic preferences of proteases with a focus on matriptase, a type II transmembrane serine protease which has been implicated in processes of cancer development, tumor progression and metastasis. I hope to obtain a selective macrocyclic substrate for matriptase which will serve as a basis in development of a macrocyclic inhibitor and activity-based probe for this enzyme.
Education
2024 – present PhD in Chemical Sciences, Wroclaw University of Science and Technology, Faculty of Chemistry, Department of Chemical Biology and Bioimagining, Wrocław, Poland. Thesis: Macrocyclic peptides for study of transmembrane serine proteases.
2023 – 2024 MSc in Biotechnology, Wroclaw University of Science and Technology, Poland. Hydrolysis of selected cell nucleus proteins with neutrophil serine proteases.
2019 – 2023 BSc in biotechnology, Wroclaw University of Science and Technology, Poland. The role of gasdermin D in neutrophils.
Publications
Wądrzyk M, Miśkiewicz J, Kasperkiewicz-Wasilewska P, Peptydowe związki makrocykliczne : nowe perspektywy w diagnostyce i terapii chorób. Wiadomości Chemiczne 78, 1405–1445 (2024), doi: 10.53584/wiadchem.2024.11.1