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Contact
bartlomiej.skinderowicz@pwr.edu.pl
L-1, room 30
LinkedIn
Research
The main scope of my research is the activity assessment of proteolytic enzymes, with a strong emphasis on cysteine proteases, particularly SENPs. My work focuses on the expansion of the chemical toolbox available for human SENPs, including fluorogenic substrates and activity-based probes (ABPs), which may facilitate a deeper understanding of the SUMOylation process and the etiology of various diseases, including cancer and neurodegenerative disorders.
My work bridges biology and chemistry, utilizing various techniques, including solid-phase peptide synthesis (SPPS), LC-MS analysis, kinetic studies, SDS-PAGE, Western blotting, protein expression, and cell-based assays.
Education
2023 – present PhD in Chemical Sciences, Wroclaw University of Science and Technology, Faculty of Chemistry, Department of Chemical Biology and Bioimaging, Wrocław, Poland.
2022 – 2023 MSc in Biotechnology, Wroclaw University of Science and Technology, Faculty of Chemistry, Wrocław, Poland; Chemical tools for cysteine protease activity investigation
2017 – 2021 BSc in Biotechnology, Wroclaw University of Science and Technology, Faculty of Chemistry, Wrocław, Poland; Comparsion of viral antigens-specific IgY antibodies isolation methods