Daniel Strub

Born: 1 October 1985, Dębno, Poland.

Hobby: archery, jazz music, paintball

Mailing address: Dapertment of Chemical Biology and Bioimaging Wrocław University of Technology,

Wybrzeże Wyspiańskiego 27,

50-370 Wrocław, Poland.

Phone office: (+48) (71) 320-20-10;

Fax office: (+48) (71) 320-24-27.

E-mail: daniel.strub@pwr.edu.pl 

Education

2009 – M.Sc. in molecular biotechnology and biocatalysis – Department of Bioorganic Chemistry, Wrocław University of Technology.

2012 – M.Sc. in organic and metaloorganic chemistry - Department of Bioorganic Chemistry, Wrocław University of Technology.

2012/2013 - Postgraduate studies: Safety in utilization and management of chemical substances, Faculty of Chemistry, University of Łódź.

2013 - Visiting Scholar, science commercialization studies: Haas School of Business, University of California Berkeley, CA, USA.

2014 - Ph.D. with honours in organic chemistry - Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Technology.

2015 - to date - Postgraduate studies: Aroma Trades Studies - University of Plymouth, UK

Professional memberships

1. British Society of Perfumers - since 2015

2. Top500 Innovators Society - since 2015

3. Young Scientists Council at Ministry of Science and Higher Education - 2015-2017

4. Science and Technology Expert of the National Centre for Research and Development - since 2017

5. Business and Economy Expert of the National Centre for Research and Development - since 2017

6. Expert of the European Commission's Research Executive Agency - since 2018

7. Member of the permanent scientific committee of International Symposium on Essential Oils - since 2018

Research interests

Research interest concern basic and applied research including:

1. Synthesis and olfactory evaluation of novel semisynthetic low-molecular fragrant compounds.

2. Evaluation of biocidal properties of terpenoid derivatives.

3. Continuous-flow chemoenzymatic synthesis in tubular reactors.

Foreign training period

2009 – Leibniz Institute of Plant Genetics and Crop Plant Research, Department of Physiology and Cell Biology, Yeast Genetics group, Gatersleben, Germany, 4 months, Leonardo da Vinci scholarship.

2013 - Haas School of Business, University of California, Berkeley, CA, USA, 9 weeks, Top500 Innovators Programme

2018 - Institute of Chemistry, Univeristy of Nice, France, 9 days

2019 - British Society of Perfumers Workshop, Towcester, UK, 4 days

Awards and honours

2017 June - International Federation of Essential Oils and Aroma Trades (IFEAT) Award for scientific achievements in the field of synthesis of new fragrances and assessment of their environmental impact.

2016 June - International Federation of Essential Oils and Aroma Trades (IFEAT) Award for achievements in the field of synthesis of chiral fragrant compounds.

2015 June - International Federation of Essential Oils and Aroma Trades (IFEAT) Award for research regarding novel semisynthetic fragrances.

2014 June - International Federation of Essential Oils and Aroma Trades (IFEAT) Award for scientific achievements and presentation titled Utilization of constituents of thuja and fennel essential oils towards synthesis of novel fragrant compounds.

2013 November - Faculty of Chemistry Dean's award for activity in favour of PhD Students community.

2012 November - Wrocław University of Technology scientific scholarship from internal funds for outstanding scientific achievements.

2012 November - Faculty of Chemistry Dean's award for outstanding scientific achievements.

2012 October - Beneficiary of Wrocław University of Technology pro-quality scholarship for scientific achievements.

2012 March - Wrocław University of Technology scientific scholarship from internal funds for outstanding scientific achievements.

2011 October - Beneficiary of Wrocław University of Technology pro-quality scholarship for scientific achievements.

2011 October - 2013 - March Beneficiary of Enterprising graduate student – an investment in innovative development of the region. Human Capital Operational Programme European Union (Przedsiębiorczy doktorant - Program Operacyjny Kapitał Ludzki).

Invited lectures

2018 - University of Nice - Continuous kinetic resolution of non-equimolar mixture of diastereoisomeric alcohol using structured monolithic enzymatic microreactor

2018 - Plenary lecture - 49th International Symposium on Essential Oils - Stereochemistry of Volatiles - the Status and Perspectives

Auxiliary Supervisionship

2019 - to date Wojciech Kołodynski, MSc, Faculty of Environmental Engineering, Wroclaw University of Science and Technology, PhD Thesis title: Toxicity evaluation of novel odorants synthesized from natural raw materials

Publications

1. Strub, D.J., Szymanska, K., Hrydziuszko, Z., Bryjak, J., Jarzebski, A.B., Continuous flow kinetic resolution of a non-equimolar mixture of diastereoisomeric alcohol using a structured monolithic enzymatic microreactor React. Chem. Eng. 2019, 4, 587. View at Publisher
2. Hrydziuszko, Z., Strub, D., Labus, K., Bryjak, J., Burkholderia cepacia lipase immobilization for hydrolytic reactions and the kinetic resolution of the non-equimolar mixtures of isomeric alcohols Bioorg Chem 2019, accepted.
3. Bak, A., Kozik V., Kozakiewicz D., Gajcy K., Strub D.J., Swietlicka A., Stepankova S., Imramovsky A., Polanski J, Smolinski A., Jampilek, J., Novel Benzene-based Carbamates for AChE/BChE Inhibition: Synthesis and Ligand/Structure-oriented SAR study Int. J. Mol. Sci. 2019, 20, 1. View at Publisher
4. Balcerzak, L., Gibka, J., Sikora, M., Kula, J., Strub, D.J., Minor constituents of essential oils and aromatic extracts. Oximes derived from natural flavor and fragrance raw materials - sensory evaluation, spectral and gas chromatographic characteristics Food Chemistry 2019, accepted.
5. Strub, D.J., Garboś, A., Lochyński, S., Synthesis, lipase catalyzed kinetic resolution, and determination of the absolute configuration of enantiomers of the Morita-Baylis-Hillman adduct 3-hydroxy-2-methylenebutanenitrile ARKIVOC 2017, 313. View at Publisher
6. Strub, D.J.; Salat, K.; Librowski, T.; Lochynski, S.; Gawel, M.; Podkowa, A., The anxiolytic-like activity of a novel N-cycloalkyl- N-benzoylpiperazine derivative. Pharm. Rep. 2016, 68, 62. View at Publisher
7. Strub, D.J.; Kula, J.; Sikora, M.; Gibka, J.; Lochynski, S., Synthesis and olfactory evaluation of homologous series of (+)- and (-)-carvone oxime ethers Flavour Frag. J. 2016, 31, 81. View at Publisher
8. Waclawczyk-Biedron, W., Frackowiak-Wojtasek, B., Strub, D., Rzechak, M., Wojtasek, H., Synthesis of the aggregation pheromone of the Colorado potato beetle from its degradation product Bioorg. Med. Chem. Lett. 2015, 17, 3560. View at Publisher
9. Kaczmarczyk, D., Strub, D., Polowy, A., Wilk, K.A., Lochyński, S., Selected Essential Oils in Cosmetic Emulsions: Process Oriented Stability Studies and Antimicrobial Activity Nat. Volatiles & Essent. Oils 2015, 2, 27.
10. Pękala, J., Strub, D.J., Kozioł, A., Lochyński, S., Variability of biological activities of limonoids derived from plant sources. Mini-Rev. Org. Chem. 2014, 11, 269. View at Publisher
11. Strub, D., Balcerzak, L., Lochyński, S., (+)-3-Carene: valuable starting material for synthesis of low-molecular compounds with olfactory properties Curr. Org. Chem. 2014, 18, 446. View at Publisher
12. Strub, D., Balcerzak, L., Niewiadomska, M., Kula, J., Sikora, M., Gibka, J., Lochyński, S., Stereochemistry of terpene derivatives. Part 8: Synthesis of terpenoids from (1S,4R)- and (1R,4S)-fenchone and their comparative odour characteristics. Tetrahedron-Asymmetr. 2014, 25, 1038. View at Publisher
13. Balcerzak L., Lipok J., Strub D.J., Lochyński S., Biotransformations of monoterpenes by photoautotrophic microorganisms J. Appl. Microb. 2014, 115, 1523. View at Publisher
14. Strub, D., Synteza pochodnych terpenoidowych o potencjalnej aktywności na centralny układ nerwowy PhD Thesis 2014, 1.
15. Kuriata-Adamusiak, R., Strub, D., Lochyński, S., Application of microorganisms towards synthesis of chiral terpenoid derivatives. Appl. Microbiol. Biot. 2012, 95, 1427. View at Publisher
16. Moniczewski, A., Librowski, T., Lochyński, S., Strub, D.,, Evaluation of the irritating influence of carane derivatives and their antioxidant properties in a deoxyribose degradation test Pharmacol Rep 2011, 63, 120.
17. Kuriata-Adamusiak, R., Strub, D., Szatkowski, P., Lochyński, S., Biotransformation of bicyclic terpenoid ketones towards new compounds with olfactory properties. Flavour Fragr. J. 2011, 26, 351. View at Publisher
18. Kuriata-Adamusiak R., Strub D., (+)-3-karen jako prekursor w syntezie biologicznie aktywnych zwiózków Na pograniczu chemii i biologii, Adam Mickiewicz University Press, Pozna? 2011, 27, 155.
19. Strub, D., Lochyński, S., Drugs enhancing learning and memory processes. Na pograniczu chemii i biologii, Adam Mickiewicz University Press, Poznan 2010, 25, 91.
20. Strub, D., Lochyński, S., Medical aspects of cognitive enhancement. Papers of Students of the Wrocław University of Technology, Wrocław University of Technology Press, Wrocław 2010, 15, 156.

Patents

18. Lochyński, S., Strub, D., O-izoamyloksyiminofenchan i sposób jego wytwarzania. PL 221469 B1, 2016

17. Lochyński, S., Strub, D., O-izobutyloksyiminofenchan i sposób jego wytwarzania. PL 221468 B1, 2016

16. Lochyński, S., Strub, D., O-alliloksyiminofenchan i sposób jego wytwarzania. PL 220071, 2015

15. Lochyński, S., Strub, D., (–)-O-n-heksyloksyiminofenchan i sposób jego wytwarzania. PL 220142, 2015

14. Lochyński, S., Strub, D., Skorupa, L., {4-[2-hydroksy-3-(4-hydroksy-3-metoksyfenylo)propylo]piperazyn-1-ylo}fenylometanon i sposób jego wytwarzania. PL 218830, 2015

13. Lochyński, S., Strub, D., (–)-O-n-amyloksyiminofenchan i sposób jego wytwarzania. PL 220070, 2015

12. Lochyński, S., Strub, D., (–)-O-2-hydroksyetyloksyiminobornan i sposób jego wytwarzania. PL 220069, 2015

11. Lochyński, S., Strub, D., (–)-(1R,4S)-{[(2R,S)-2,3-epoksy]propoksyimino}fenchan i sposób jego wytwarzania. PL 397363 B1, 2015

10. Lochyński, S., Strub, D., (–)-(1R)-(butyroksyimino)fenchan i sposób jego wytwarzania. PL 398493 B1, 2014

9. Lochyński, S., Strub, D., (–)-(1R, 4S)-(etoksyimino)fenchan i sposób jego wytwarzania. PL 398494 B1, 2014

8. Lochyński, S., Strub, D., Eter metylowy oksymu (–)-fenchonu i sposób jego wytwarzania. PL 398495 B1, 2014

7. Lochyński, S., Strub, D., Iminowa pochodna (–)-fenchonu i sposób jej wytwarzania. PL 398496 B1, 2014

6. Lochyński, S., Strub, D., Kuriata-Adamusiak, R. Chlorowodorek (–)-1-[(1S,3R)-3-[2-(4-benzoilopiperazyn-1-ylo)etylo]-2,2-dimetylocyklopropylo]propan-2-onu i sposób jego wytwarzania. PL 213903 B1, 2013

5. Lochyński, S., Strub, D., Chlorowodorek (-)-(1R)-2-[(3-N-benzoilopiperazynylo-(2R,S)-hydroksy)propoksyimino]bornanu i sposób jego wytwarzania. PL 213887 B1, 2013

4. Lochyński, S., Strub, D., Skorupa, L., Chlorowodorek N-benzoilo-N-1-(2-fenylopropylo)piperazyny i sposób jego wytwarzania. PL 213902 B1, 2013

3. Lochyński, S., Strub, D., Skorupa, L., Kuriata-Adamusiak, R., Terpenoidowa pochodna N-benzoilopiperazyny i sposób jej wytwarzania. PL 213888 B1, 2013

2. Lochyński, S., Strub, D. Oksym (+)-(1S,4R,5S)-4-izopropenylo-1-metylobicyklo[3.1.0]heksan-2-onu i sposób jego wytwarzania PL 214603 B1, 2013

1. Lochyński S., Gajcy, K., Strub, D., Nowy chiralny hydroksykarbaminian dimetylocyklopropanu i sposób jego wytwarzania. PL 212624 B1, 31.10.2012

Patent Applications

1. Lochyński, S., Strub, D., Balcerzak, L., (–)-(1R,4S)-{[(2R)-2,3-epoksy]propoksyimino}fenchan i sposób jego wytwarzania. Polish Patent Application, P-404963, 02.08.2013

Conference Communications

24. Strub, D.J., Lochyński, S. Stereochemistry of Volatiles - the Status and Perspectives 49th International Symposium on Essential Oils, Nis, 13-16.09.2018

23. Surowiak, A.J., Dudek, A., Lochyński, S., Strub, D. Microbial growth inhibition by oximes derived from natural volatile carbonyl compounds 49th International Symposium on Essential Oils, Nis, 13-16.09.2018

22. Strub, D.J., Balcerzak, L., Gibka, J., Sikora, M., Kula, J. Rzadkie składniki olejków eterycznych i ekstraktów zapachowych. Oksymy uzyskane z surowców zapachowych pochodzenia naturalnego Naturalne i Syntetyczne Produkty Zapachowe i Kosmetyczne, Łódź, 2-4.07.2018

21. Surowiak, A., Lochyński, S., Strub, D.J. Aktywność przeciwbakteryjna i przeciwgrzybicza lotnych oksymów Naturalne i Syntetyczne Produkty Zapachowe i Kosmetyczne, Łódź, 2-4.07.2018

20. Surowiak, A., Lochyński, S., Strub, D.J. Antimicrobial activity of low-molecular oximes 4th Symposium on Biotransformations for Pharmaceutical and Cosmetic Industry, Trzebnica, 25-27.06.2018

19. Hrydziuszko, Z., Strub, D.J., Labus, K., Bryjak, J. Immobilization of lipase for effective resolution of diastereoisomers in a repetitive batch reactor 4th Symposium on Biotransformations for Pharmaceutical and Cosmetic Industry, Trzebnica, 25-27.06.2018

18. Surowiak, A., Gibka, J., Błaszczyk, M., Kula, J., Balcerzak, L., Sikora, M., Surowiak, A., Lochyński, S., Piekarska, K., Strub, D.J. Synteza, charakterystyka zapachowa i wstępne badania toksyczności eterów oksymu cytralu 60 Zjazd PTChem, Wrocław, 17-21.09.2017

17. Strub, D.J., Gibka, J., Błaszczyk, M., Kula, J., Balcerzak, L., Sikora, M., Surowiak, A., Lochyński, S., Piekarska, K., Synthesis, olfactory evaluation and preliminary environmental impact of citral oxime ethers 48th International Symposium on Essential Oils, Pecs, Hungary, 10-13.09.2017

16. Balcerzak, L., Gibka, J., Błaszczyk, M., Kula, J., Sikora, M., Lochyński, S., Piekarska, K., Strub, D.J. Synteza i analiza profilu zapachowego azotowych pochodnych cytralu oraz badania wstępne dotyczące ich wpływu na środowisko naturalne Chemia dla Urody i Zdrowia, Toruń, Poland, 8-10.06.2017

15. Strub, D., Hrydziuszko, Z., Bryjak, J., Szymańska, K., Jarzębski, A., Lochyński, S. Batch and continuous-flow biocatalytic transesterification of chiral fragrant terpenoid alcohols 47th International Symposium on Essential Oils, Nice, France, 11-14.09.2016

14. Strub, D., Kula, J., Lochyński, S. Main constituents of Carum carvi seeds and Mentha spicata essential oils as substrates for preparation of novel fragrant compounds with preserved terpene backbone 46th International Symposium on Essential Oils, Lublin, Poland, 13-16.09.2015

13. Strub, D., Kula, J., Sikora, M., Gibka, J., Lochyński, S. Chemoenzymatyczna synteza i analiza właściwości zapachowych eterów oksymów o szkielecie terpenowym. VI Krajowe Sympozjum: Naturalne i Syntetyczne Produkty Zapachowe i Kosmetyczne, Łódź, Poland, 24-26.06.2015

12. Strub, D., Kula, J., Lochyński, S. Utilization of constituents of thuja and fennel essential oils towards synthesis of novel fragrant compounds. 45th International Symposium on Essential Oils, Istanbul, Turkey, 7-10.09.2014

11. Strub, D., Sałat, K., Librowski, T., Lochyński, S. Synthesis and Preliminary Pharmacological Evaluation of two Novel N-benzoylpiperazine Derivatives as Potential Agents for the Treatment of Affective Disorders. 22nd Neuropharmacology Conference: Cognitive Enhancers, New Orleans, USA, 10-11.10.2012

10. Strub, D., Skorupa, L., Kuriata-Adamusiak, R. Utilization of common plants secondary metabolites towards preparation of biologically active compounds. 8th Plant Science Student Conference, Gatersleben, Germany, 4-7.06.2012

9. Strub, D., Lochyński, S., Synthesis and Chiral Gas Chromatographic Resolution of Epoxyiminoethers Derived from Natural Terpene Ketones. 8th International Symposium on Chromatography of Natural Products, Lublin, 17-20.05.2012

8. Skorupa, L., Lochyński, S., Strub, D., Synthesis of new N-benzoylpiperazine derivatives with potential procognitive activity. 54 Zjazd PTChem, Lublin, 18-22.09.2011

7. Strub, D., Lochyński, S., Synthesis of new bicyclic lactam from (+)-3-carene via Beckmann rearrangement. 41st International Symposium on Essential Oils, Wrocław, 5-8.09.2010

6. Strub, D., Lochyński, S., Medical aspects of cognitive enhancement. 8th Students Science Conference, Szklarska Poręba, 23-25.08.2010

5. Strub, D., Lochyński, S., Lactams as valuable monomers in polymer industry. Phobia Annual Nanophotonics International Conference, Wrocław, 28-30.04.2010

4. Strub, D., Lochyński, S., Lactams as cognitive enhancers. Referat, VIII Ogólnopolskie Seminarium Doktorantów “Na pograniczu biologii i chemii”, Duszniki Zdrój, 24-27.04.2010

3. Strub, D., Lochyński, S. Synteza pochodnych piperyd-2-onu z (+)-3-karenu o potencjalnych właściwościach prokognitywnych. Zjazd Wiosenny Sekcji Studenckiej Polskiego Towarzystwa Chemicznego, Sokolec, 7-11.04.2010;

2. Gajcy, K., Strub, D., Lochyński, S., New gem-dimethylcyclopropane derivatives as GABA analogues. 51 Zjazd PTChem, Łódź, 09.2009

1. Gajcy K., Strub, D, Librowski, T., Lochyński, S., Non-protein amino acids as GABA analogs having potential neuroactivity. Join Meeting Medicinal Chemistry, Budapest, Hungary, 24-28.06.2009