Fix NeutRopenia (FIXNET): focusing on neutrophil proteases defects which serve as novel diagnostic and therapeutic options

Neutrophil granulocytes (NGs) are the most abundant leukocyte population and their disfunction frequently affects vaccination program and is linked with a high risk of life-threatening infection (in Poland approx. 3.000 children/yr). NGs contain specialized set of granules which incorporate a number of functionally important proteins including specific neutrophil serine proteases (NSPs). Genetic mutations of NSPs frequently lead to NGs defects. Thus, NSPs are essential for neutrophil development and action. The main objective of the current project is to marge clinical and genomic data with molecular biology of NSPs and unique highly selective chemical tools for identification of their role in NGs disfunction. Joined efforts of three academic centers as an established the FIXNET consortium will work together to reach this goal. This will develop cutting-edge diagnostics and will explore new therapeutic horizons for patients with rare and common diseases associated with NGs disfunction.

No POIR.04.04.00-00-16D7/18-00

TEAM-NET Programme within The Smart Growth Operational Programme 2014-2020 Priority IV INCREASING THE SCIENTIFIC RESEARCH POTENTIAL, Measure 4.4: Increasing the human potential in the R&D sector

Project Leader: prof. Wojciech Młynarski

Leader: Medical University of Lodz

Partner: Jagiellonian University