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Department of Chemical Biology and Bioimaging

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      1. Rut W, Groborz K, Zhang L, Modrzycka S, Poreba M, Hilgenfeld R, Drag M, Profiling of flaviviral NS2B-NS3 protease specificity provides a structural basis for the development of selective chemical tools that differentiate dengue from Zika and West Nile virusesAntiviral Research 2020, 1.
      2. Poreba M, Protease-activated prodrugs: strategies, challenges and future directionsFEBS Journal 2020, 1.
      3. Poreba M, Groborz K, Navarro M, Snipas SJ, Drag M, Salvesen GS, Caspase selective reagents for diagnosing apoptotic mechanismsCell Death and Differentiation 2019, 26, 229.
      4. Cogo F, Poreba M, Rut W, Groborz K, Smyth P, Johnston MC, Williams R, Longley DB, Burden RE, Salvesen GS, Drag M, Scott Ch., Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probeNanoscale 2019, 11, 742.
      5. Strub, D.J., Szymanska, K., Hrydziuszko, Z., Bryjak, J., Jarzebski, A.B., Continuous flow kinetic resolution of a non-equimolar mixture of diastereoisomeric alcohol using a structured monolithic enzymatic microreactor Chem. Eng. 2019, 4, 587.
      6. Hrydziuszko, Z., Strub, D., Labus, K., Bryjak, J., Burkholderia cepacia lipase immobilization for hydrolytic reactions and the kinetic resolution of the non-equimolar mixtures of isomeric alcoholsBioorg Chem 2019, accepted.
      7. Kozioł, A., Jasnowski, M., Grela, E., Szczepanik, M., Gabryś, B., Dancewicz, K., Lochyński, S.,, Synthesis and Biological Activity of New 4-tert-Butylcyclohexanone Derivatives Biodiversity 2019, 16, 1.
      8. Kozioł, A., Grela, E., Macegoniuk, K.M., Grabowiecka, A., Lochyński, S., Synthesis of nitrogen-containing monoterpenoids with antibacterial activity Prod. Res., 2019, 1.
      9. Bak, A., Kozik V., Kozakiewicz D., Gajcy K., Strub D.J., Swietlicka A., Stepankova S., Imramovsky A., Polanski J, Smolinski A., Jampilek, J., Novel Benzene-based Carbamates for AChE/BChE Inhibition: Synthesis and Ligand/Structure-oriented SAR study J. Mol. Sci. 2019, 20, 1.
      10. Poreba M, Rut W, Groborz K, Snipas SJ, Salvesen GS, Drag M, Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cellsCell Death and Differentiation 2019, 26, 2695.
      11. Poreba M, Recent advances in the development of legumain-selective chemical probes and peptide prodrugsBiological Chemistry 2019, 1.
      12. Groborz K, Kolt S, Kasperkiewicz P, Drag M, Internally Quenched Fluorogenic substrates with unnatural amino acids for cathepsin G investigationBiochimie 2019, 166, 103.
      13. de Vries LE, Sanchez MI, Groborz K, Kuppens L, Poreba M, Lehmann C, Nevins N, Withers-Martinez C, Hirst DJ, Yuan F, Arastu-Kapur S, Horn M, Mares M, Bogyo M, Drag M, Deu E, Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide-based substrates and covalent inhibitorsFEBS Journal 2019, 286, 3998.
      14. Groborz K, Gonzalez-Ramirez ML, Snipas SJ, Salvesen GS, Drag M, Poreba M, Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells Cell Death and Differentiation2019, 1.
      15. Drąg-Zalesińska M, Rembiałkowska N, Borska S, Saczko J, Drąg M, Poręba M, Kulbacka J, A New Betulin Derivative Stimulates the Synthesis of Collagen in Human Fibroblasts Stronger than its PrecursorIn vivo 2019, 33, 1087.
      16. Balcerzak, L., Gibka, J., Sikora, M., Kula, J., Strub, D.J., Minor constituents of essential oils and aromatic extracts. Oximes derived from natural flavor and fragrance raw materials - sensory evaluation, spectral and gas chromatographic characteristicsFood Chemistry 2019, accepted.
      17. Poreba M, Groborz K, Vizovisek M, Maruggi M, Turk D, Turk B, Powis G, Drag M, Salvesen GS, Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples Chemical Science2019, 10, 8461.
      18. Rut W, Nielsen NV, Czarna J, Poreba M, Kanse SM, Drag M, Fluorescent activity-based probe for the selective detection of Factor VII activating protease (FSAP) in human plasmaThrombosis Research 2019, 182, 124.
      19. Babin BM, Kasperkiewicz P, Janiszewski T, Yoo E, Drag M, Bogyo M, Leveraging peptide substrate libraries to design inhibitors of bacterial Lon proteaseACS Chemical Biology 2019, 1.
      20. Anderson BM, Poole DP, Aurelio L, Ng GZ, Fleischmann M, Kasperkiewicz P, Morissette C, Drag M, van Driel IR, Schmidt BL, Vanner SJ, Bunnett NW, Edgington-Mitchell LE, Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel diseaseScientific Reports 2019, 9, 13295.
      21. Poreba M, Groborz K, Rut W, Pore M, Snipas SJ, Vizovisek M, Turk B, Drag M, Salvesen GS, The Activome: multiplexed probing of activity of proteolytic enzymes using mass cytometry-compatible activity-based probes (TOF-probes)bioRxiv 2019, 1.
      22. Aaltonen N, Singha P, Jakupovic H, Wirth T, Samaranayake H, Pasonen-Seppanen S, Rilla K, Varjosalo M, Edgington-Mitchell L, Kasperkiewicz P, Drag M, Kalvala S, Moisio E, Savinainen JR, Laitinen JT, Tissue-ABPP enables high-resolution confocal fluorescence imaging of serine hydrolase activity in cryosections – Application to glioma brain unveils activity hotspots originating from tumor-associated neutrophilsbioRxiv 2019, 1.
      23. Maluch I, Czarna J, Drag M, Applications of unnatural amino acids in protease probesChemistry - An Asian Journal 2019, 14, 4103.
      24. Lunde NN, Gregersen I, Ueland T, Shetelig C, Holm S, Kong XY, Michelsen AE, Otterdal K, Yndestad A, Broch K, Gullestad L, Nyman TA, Bendz B, Eritsland J, Hoffmann P, Skagen K, Gonçalves I, Nilsson J, Grenegard M, Poreba M, Drag M, Seljeflot I, Sporsheim B, Espevik T, Skjelland M, Johansen HT, Solberg R, Aukrust P, Björkbacka H, Andersen GO, Halvorsen B, Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages.Atherosclerosis 2019, 1.
      25. Poreba M, Rut W, Vizovisek M, Groborz K, Kasperkiewicz P, Finlay D, Vuori K, Turk D, Turk B, Salvesen GS, Drag M, Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probesChemical Science 2018, 9, 2113.
      26. Gonzalez-Ramirez ML*, Poreba M*, Snipas SJ, Groborz K, Drag M, Salvesen GS (* equal contribution), Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1Journal of Biological Chemistry 2018, 293, 7058.
      27. Stach N, Kalinska M, Zdzalik M, Kitel R, Karim A, Serwin K, Rut W, Larsen K, Jabaiah A, Firlej M, Wladyka B, Daugherty P, Stennicke H, Drag M, Potempa J, Dubin G, Unique Substrate Specificity of SplE Serine Protease from Staphylococcus aureusStructure 2018, 26, 572.
      28. Poreba M, Kasperkiewicz P, Rut W, Drag M, Screening Combinatorial Peptide Libraries in Protease Inhibitor Drug DiscoveryExtracellular Targeting of Cell Signaling in Cancer: Strategies Directed at MET and RON Receptor Tyrosine Kinase Pathways, 1 2018, 1.
      29. Rut W, Poreba M, Kasperkiewicz P, Snipas SJ, Drag M, Selective substrates and activity-based probes for imaging of the human constitutive 20S proteasome in cells and blood samplesJournal of Medicinal Chemistry 2018, 61, 5222.
      30. Barry R, John SW, Liccardi G, Tenev T, Jaco J, Chen Ch, Choi J, Kasperkiewicz P, Fernandes-Alnemri T, Alnemri E, Drag M, Chen Y, Meier P, SUMO-mediated regulation of NLRP3 modulates inflammasome activityNature Communications 2018, 9, 3001.
      31. Vizovisek M, Vidmar R, Drag M, Fonovic M, Salvesen GS, Turk B, Protease Specificity: Towards In Vivo Imaging Applications and Biomarker DiscoveryTrends in Biochemical Sciences 2018, 1, 1.
      32. Sikorska E, Stachurski O, Neubauer D, Małuch I, Wyrzykowski D, Bauer M, Brzozowski K, Kamysz W, Short arginine-rich lipopeptides: from self-assembly to antimicrobial activityBiochimica et Biophysica Acta. Biomembranes 2018, 1860, 2242.
      33. Świderska KW, Szlachcic A, Opaliński Ł, Zakrzewska M, Otlewski J, FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and ?-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1International Journal of Molecular Sciences 2018, 19, 2098.
      34. Kasperkiewicz P, Kołt S, Janiszewski T, Groborz K, Poręba M, Snipas SJ, Salvesen GS, Drąg M, Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probesScientific Reports 2018, 8, 15998.
      35. Kozioł, A., Frątczak, J., Grela, E., Szczepanik, M., Gabryś, B., Dancewicz, K., Lochyński, S.,, Synthesis and biological activity of new derivatives with the preserved carane system Prod. Res., 2018, 1.
      36. Kozioł, A.,Macegoniuk, K.M., Grela, E., Grabowiecka, A., Biernat, M., Lochyński, S., Synthesis of terpenoid oxo derivatives with antiureolytic activity Biol. Rep., 2018, 1.
      37. Sokoła-Wysoczańska, E., Wysoczański, T., Wagner, J., Czyż, K., Bodkowski, R., Lochyński, S., Patkowska-Sokoła, B.,, Polyunsaturated fatty acids and their potential therapeutic role in cardiovascular system disorders - a review. Nutrients,2018, 10, 1561.
      38. Malek N, Starowicz K., Joint problems arising from lack of repair mechanisms: can cannabinoids help?British Journal of Pharmacology 2018, 1.
      39. Korostynski M, Malek N, Piechota M, Starowicz K., Cell-type-specific gene expression patterns in the knee cartilage in an osteoarthritis rat modelFunctional & Integrative Genomics 2018, 18, 79.
      40. Mlost J, Kostrzewa M, Malek N, Starowicz K, Molecular Understanding of the Activation of CB1 and Blockade of TRPV1 Receptors: Implications for Novel Treatment Strategies in OsteoarthritisInternational Journal of Molecular Sciences 2018, 19, 342.
      41. Strub, D.J., Garboś, A., Lochyński, S., Synthesis, lipase catalyzed kinetic resolution, and determination of the absolute configuration of enantiomers of the Morita-Baylis-Hillman adduct 3-hydroxy-2-methylenebutanenitrileARKIVOC 2017, 313.
      42. Teixeira PF, Kmiec B, Branca RM, Murcha MW, Byzia A, Ivanova A, Whelan J, Drag M, Lehtiö J, Glaser E., A multi-step peptidolytic cascade for amino acid recovery in chloroplasts.Nature Chemical Biology 2017, 13, 15.
      43. Balogh B, Dahmen M, Stahl M, Poreba M, Gersch M, Drag M, Sieber SA , Insights into ClpXP proteolysis: heterooligomerization and partial deactivation enhance chaperone affinity and substrate turnover in Listeria monocytogenesChemical Science 2017, 8, 1592.
      44. Rut W, Zhang L, Kasperkiewicz P, Poreba M, Hilgenfeld R, Drag M, Extended substrate specificity and first potent irreversible inhibitor/activity-based probe design for Zika virus NS2B-NS3 proteaseAntiviral Research 2017, 139, 88.
      45. Kasperkiewicz P, Poreba M, Groborz K, Drag M, Emerging challenges in the design of selective protease substrates, inhibitors and activity-based probes for indistinguishable proteasesFEBS Journal 2017, 284, 1518.
      46. Drag-Zalesinska M, Drag M, Poreba M, Borska S, Kulbacka J, Saczko J, Anticancer properties of ester derivatives of betulin in human metastatic melanoma cells (Me-45)Cancer Cell International 2017, 17, 7.
      47. Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen GS, Drag M, Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease familiesScientific Reports 2017, 7, 43135.
      48. Poreba M, Salvesen GS, Return of the Ice Age: Caspases Safeguard against Inflammatory Cell DeathCell Chemical Biology 2017, 24, 550.
      49. Lunde NN, Haugen MH, Bodin Larsen KB, Damgaard I, Pettersen SJ, Kasem R, Rut W, Drag M, Poreba M, Johansen HT, Solberg R, Glycosylation is important for legumain localization and processing to active forms but not for cystatin E/M inhibitory functionsBiochimie 2017, 139, 27.
      50. Kasperkiewicz P, Altman Y, D'Angelo M, Salvesen GS, Drag M, A toolbox of fluorescent probes for parallel imaging reveals uneven location of serine proteases in neutrophilsJournal of the American Chemical Society 2017, 139, 10115.
      51. Poreba M, Salvesen GS, Drag M, Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificityNature Protocols 2017, 12, 2189.
      52. Małuch I, Levesque C, Kwiatkowska A, Couture F, Ly K, Desjardins R, Neugebauer W, Prahl A, Day R, Positional scanning identifies the molecular determinants of a high affinity multi-Leucine inhibitor for furin and PACE4Journal of Medicinal Chemistry 2017, 60, 2732.
      53. Swiderska KW, Szlachcic A, Czyrek A, Zakrzewska M, Otlewski J, Site-specific conjugation of fibroblast growth factor 2 (FGF2) based on incorporation of alkyne-reactive unnatural amino acid.Bioorganic & Medicinal Chemistry 2017, 25, 3685.
      54. Krzyscik M; Zakrzewska M; Sorensen V; Sokolowska-Wedzina A; Lobocki M; Swiderska KW; Krowarsch D.; Wiedlocha A.; Otlewski J., Cytotoxic Conjugates of Fibroblast Growth Factor 2 (FGF2) with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF ReceptorsACS Omega 2017, 2, 3792.
      55. Kozioł, A., Mroczko, L., Niewiadomska, M., Lochyński, S., ?-Lactones with potential biological activity  J. Natur. Sc.,2017, 32, 495.
      56. Surowiak, A., Lochyński, S.,, Aktywność biologiczna oksymów. W:Na pograniczu chemii i biologii. Wydawnictwo Naukowe UAM, Poznań 2017, 37, 21.
      57. Lopes DM*, Malek N*, Edye M, Jager SB, McMurray S, McMahon SB, Denk F (*equal contribution), Sex differences in peripheral not central immune responses to pain-inducing injuryScientific Reports 2017, 7, 16460.
      58. Pajak A, Kostrzewa M, Malek N, Korostynski M, Starowicz K, “Expression of matrix metalloproteinases and components of the endocannabinoid system in the knee joint are associated with biphasic pain progression in a rat model of osteoarthritisJournal of Pain Research 2017, 1973.
      59. Korostyński M, Malek N, Piechota M, Starowicz K, Blood Transcriptional Signatures for Disease Progression in a Rat Model of OsteoarthritisInternational Journal of Genomics 2017, 1746426.
      60. Strub, D.J.; Salat, K.; Librowski, T.; Lochynski, S.; Gawel, M.; Podkowa, A., The anxiolytic-like activity of a novel N-cycloalkyl- N-benzoylpiperazine derivative. Rep. 2016, 68, 62.
      61. Strub, D.J.; Kula, J.; Sikora, M.; Gibka, J.; Lochynski, S., Synthesis and olfactory evaluation of homologous series of (+)- and (-)-carvone oxime ethersFlavour Frag. J. 2016, 31, 81.
      62. Gersch M, Stahl M, Poreba M, Dahmen M, Dziedzic A, Drag M, Sieber SA, Barrel-shaped ClpP proteases display attenuated cleavage specificityACS Chemical Biology 2016, 11, 389.
      63. Byzia, A.; Szeffler, A.; Kalinowski, L.; Drąg, M., Activity profiling of aminopeptidases in cell lysates using a fluorogenic substrate libraryBiochimie 2016, 122, 31.
      64. Wysoczański, T., Sokoła-Wysoczańska, E., Pękala, J., Lochyński, S., Czyż K., Bodkowski, R., Herbinger, G., Patkowska-Sokoła, B., Librowski, T., Omega-3 Fatty Acids and their Role in Central Nervous System - A Review Med. Chem. 2016, 23, 816.
      65. Modak, J. K.; Rut, W.; Wijeyewickrema, L. C.; Pike, R. N.; Drąg, M.; Roujeinkova, A., Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidaseBiochimie 2016, 121, 60.
      66. Rut, W.; Drąg, M., Human 20S proteasome activity towards fluorogenic peptides of various chain lengths Chem. 2016, 396, 921.
      67. Drinkwater N, Sivaraman KK, Bamert RS, Rut W, Mohamed K, Vinh NB, Scammells PJ, Drag M, McGowan S, Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparumBiochemical Journal 2016, 473, 3189.
      68. Poreba M, Solberg R, Rut W, Lunde NN, Kasperkiewicz P, Snipas SJ, Mihelic M, Turk D, Turk B, Salvesen GS, Drag M., Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and ProbesCell Chemical Biology 2016, 23, 1023.
      69. Lentz CS, Ordonez AA, Kasperkiewicz P, La Greca F, O'Donoghue AJ, Schulze CJ, Powers JC, Craik CS, Drag M, Jain SK, Bogyo M, Design of Selective Substrates and Activity-Based Probes for Hydrolase Important for Pathogenesis 1 (HIP1) from Mycobacterium tuberculosis.ACS infectious diseases 2016, 2, 807.
      70. Malek N, Starowicz K, Dual-Acting Compounds Targeting Endocannabinoid and Endovanilloid Systems—A Novel Treatment Option for Chronic Pain ManagementFrontiers in Pharmacology 2016, 7, 257.
      71. Malek N, Kostrzewa M, Makuch W, Pajak A, Kucharczyk M, Piscitelli F, Przewlocka B, Di Marzo V, Starowicz K, The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic painPharmacological Research 2016, 111, 251.
      72. Hachmann, J.; Edgington-Mitchell, L. E.; Poreba, M.; Sanman, L. E.; Drag, M.; Bogyo, M.; Salvesen, G. S., Probes to Monitor Activity of the Paracaspase MALT1 Biol. 2015, 22, 139.
      73. Lechtenberg, B. C.; Kasperkiewicz, P.; Robinson, H.; Drag, M.; Riedl, S. J., The Elastase-PK101 structure: Mechanism of an ultrasensitive activity-based probe revealedACS Chem. Biol. 2015, 10, 945.
      74. Rut, W.; Kasperkiewicz, P.; Byzia, A.; Poreba, M.; Groborz, K.; Drag, M., Recent advances and concepts in substrate specificity determination of proteases using tailored libraries of fluorogenic substrates with unnatural amino acids Chem. 2015, 396, 329.
      75. Arya, T.; Reddi, R.; Kishor, C.; Ganji, R.J.; Bhukya, S.; Gumpena, R.; McGowan, S.; Drag, M.; Addlagatta, A., Identification of the molecular basis of inhibitor selectivity between the human and Streptococcal Type I methionine aminopeptidases. Med. Chem. 2015, 58, 2350.
      76. Hachmann J, Edgington-Mitchell LE, Poreba M, Sanman LE, Drag M, Bogyo M, Salvesen GS., Probes to monitor activity of the paracaspase MALT1Chemistry & biology 2015, 22, 139.
      77. Bekes, M.; Rut, W.; Kasperkiewicz, P. Mulder, M. P.; Ovaa, H.; Drag, M.; Lima, C. D.; Huang, T. T., SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme. J. 2015, 468, 215.
      78. Waclawczyk-Biedron, W., Frackowiak-Wojtasek, B., Strub, D., Rzechak, M., Wojtasek, H., Synthesis of the aggregation pheromone of the Colorado potato beetle from its degradation product Med. Chem. Lett. 2015, 17, 3560.
      79. Drag-Zalesinska M, Wysocka T, Borska S, Drag M, Poreba M, Choromanska A, Kulbacka J, Saczko J., The new esters derivatives of betulin and betulinic acid in epidermoid squamous carcinoma treatment - In vitro studies.Biomedicine & Pharmacotherapy 2015, 72, 91.
      80. Kasperkiewicz P, Poreba M, Snipas SJ, Lin SJ, Kirchhofer D, Salvesen GS, Drag M., Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4.PLoS One 2015, 10, 1.
      81. Rajkovic, J.; Poreba, M.; Caglic, D.; Vidmar, R.; Wilk, A.; Borowik, A.; Salvesen, G. S.; Turk, V.; Drag, M.; Turk, B., Biochemical Characterization and Substrate Specificity of Autophagin-2 from the Parasite Trypanosoma cruzi Biol. Chem. 2015, 290, 28231.
      82. Galiullina RA, Kasperkiewicz P, Chichkova NV, Szalek A, Serebryakova MV, Poreba M, Drag M, Vartapetian AB, Substrate Specificity and Possible Heterologous Targets of Phytaspase, a Plant Cell Death Protease.Journal of Biological Chemistry 2015, 290, 24806.
      83. Poreba M, Szalek A, Kasperkiewicz P, Rut W, Salvesen GS, Drag M, Small Molecule Active Site Directed Tools for Studying Human CaspasesChemical Reviews 2015, 115, 12546.
      84. Byzia A, Szeffler A, Kalinowski L, Drag M, Activity profiling of aminopeptidases in cell lysates using a fluorogenic substrate library.Biochimie 2015, 15, 00310.
      85. van der Linden WA, Segal E, Child MA, Byzia A, Drąg M, Bogyo M., Design and Synthesis of Activity-Based Probes and Inhibitors for Bleomycin Hydrolase.Chem Biol 2015, 22, 995.
      86. van der Linden, W. A.; Segal, E.; Child, M. A.; Byzia, A. Drąg, M.; Bogyo, M., Design and Synthesis of Activity-Based Probes and Inhibitors for Bleomycin Hydrolase Biol. 2015, 22, 995.
      87. Kaczmarczyk, D., Strub, D., Polowy, A., Wilk, K.A., Lochyński, S., Selected Essential Oils in Cosmetic Emulsions: Process Oriented Stability Studies and Antimicrobial Activity Volatiles & Essent. Oils 2015, 2, 27.
      88. Kaczmarczyk, D., Lochyński, S., Microorganisms present in products of biotransformation of tea. J. Cosmetol. 2015, 18, 241.
      89. Kaczmarczyk D., Lochyński S., Kombucha broth as a natural source of organic acidsNa pograniczu chemii i biologii, Wydawnictwo Naukowe UAM, Poznań 2015, 35, 13.
      90. Stryjewska, A., Lochyński, S., Biosynthesis of two new derivatives with a fenchane unit, obtained by biotransformation with Aspergillus niger ATCC 10549PhD Interdysciplinary Journal 2015, 1, 133.
      91. Szmigiel, B.; Żymańczyk-Duda, E.; Lochyński, S., Procedura zabiegowa eksfoliacji z zastosowaniem hydroksykwasów. J. Cosmet. 2015, 18, 119.
      92. Sochaj AM, Świderska KW, Otlewski J, Current methods for the synthesis of homogeneous antibody-drug conjugatesBiotechnology Advances 2015, 33, 775.
      93. Malek N, Popiolek-Barczyk K, Mika J, Przewlocka B, Starowicz K, Anandamide, acting via CB2 receptors, alleviates LPS-induced neuroinflammation in rat primary microglial culturesNeural Plasticity 2015, 130639.
      94. Mika J, Jurga A, Starnowska J, Wasylewski M, Rojewska E, Makuch W, Malek N, Przewlocka B, Effects of chronic doxepin and amitriptyline administration in naive mice and in neuropathic pain mice modelNeuroscience 2015, 294, 38.
      95. Malek N, Mrugala M, Makuch W, Kolosowska N, Przewlocka B, Binkowski M, Czaja M, Morera E, Di Marzo V, Starowicz K, A multi-target approach for pain treatment - dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritisPain 2015, 156, 890.
      96. Malek N, Pajak A, Kolosowska N, Kucharczyk M, Starowicz K, The importance of TRPV1-sensitisation factors for the development of neuropathic painMolecular and cellular neurosciences 2015, 65, 1.
      97. Poręba, M.; Mihelic, M.; Krai, P.; Rajkovic, J.; Krężel, A.; Pawełczak, M.; Klemba, M.; Turk, D.; Turk, B.; Latajka, R.; Drąg, M., Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C.Amino Acids 2014, 46, 931.
      98. Kasperkiewicz, P.; Poreba, M.; Snipas, S. J.; Parker, H.; Winterbourn, C. C.; Salvesen, G. S.; Drag, M., Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling. Proc. Natl. Acad. Sci. U. S. A. 2014, 111, 2518. 
      99. Byzia, A; Haeggström, J.Z.; Salvesen, G.S.; Drąg, M., A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids. Amino Acids 2014, 46, 1313. 
      100. Poręba, M.; Szalek, A.; Kasperkiewicz, P.; Drąg, M., Positional Scanning Substrate Combinatorial Library (PS-SCL) Approach to Define Caspase Substrate Specificity. Methods Mol. Biol. 2014, 1133, 41. 
      101. Balcerzak L., Lipok J., Strub D.J., Lochyński S., Biotransformations of monoterpenes by photoautotrophic microorganisms J. Appl. Microb. 2014, 115, 1523.
      102. Strub, D., Balcerzak, L., Niewiadomska, M., Kula, J., Sikora, M., Gibka, J., Lochyński, S., Stereochemistry of terpene derivatives. Part 8: Synthesis of terpenoids from (1S,4R)- and (1R,4S)-fenchone and their comparative odour characteristics. Tetrahedron-Asymmetr. 2014, 25, 1038. 
      103. Strub, D., Balcerzak, L., Lochyński, S., (+)-3-Carene: valuable starting material for synthesis of low-molecular compounds with olfactory properties Curr. Org. Chem. 2014, 18, 446.
      104. Pękala, J., Strub, D.J., Kozioł, A., Lochyński, S., Variability of biological activities of limonoids derived from plant sources. Mini-Rev. Org. Chem. 2014, 11, 269.
      105. Malek N, Kucharczyk M, Starowicz K, Alterations in the anandamide metabolism in the development of neuropathic pain BioMed Research International 2014, 686908
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      117. Zeiler, E.; List, A.; Alte, F.; Gersch, M.; Wachtel, R.; Poręba, M.; Drąg, M.; Groll, M.; Sieber, S.A., Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad. Proc. Natl. Acad. Sci. U. S. A. 2013, 110, 11302. 
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      142. Pop, C.; Oberst, A.; Drąg, M.; Van Raam, B. J.; Riedl, S. J.; Green, D. R.; Salvesen, G. S. , FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity. Biochem J. 2011, 433, 447. 
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      144. Śleszyńska M, Wierzba TH, Malinowski K, Borovičková L, Małuch I, Sobolewski D, Lammek B, Slaninová J, Prahl A, Novel analogues of bradykinin conformationally restricted in the C-terminal part of the molecule Journal of Peptide Science 2011, 17, 366
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      150. Shu, C.-W.; Drąg, M.; Bekes, M.; Zhai, D.; Salvesen, G. S.; Reed, J. C., Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4). Autophagy 2010, 6, 936. 
      151. Łęgowska A, Bulak E, Jaśkiewicz A, Małuch I, Sieracki M, Wysocka M, Lesner A, Rolka K, Analogues of trypsin inhibitor SFTI-1 with disulfide bridge substituted by various length of carbonyl bridges Protein and Peptide Lettera 2010, 17, 1223.
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      160. Podstawka, E.; Kudelski, A.; Drąg, M.; Oleksyszyn, J.; Proniewicz, L. M., Adsorbed states of substituted ?-aminophosphinic acids on silver electrode surface. Comparison with colloidal silver substrate. J. Raman Spect. 2009, 11, 1578. 
      161. Podstawka, E.; Drąg, M.; Oleksyszyn, J., Raman and surface-enhanced Raman studies of ?-aminophosphinic inhibitors of metalloenzymes. J. Raman Spect. 2009, 11, 1564. 
      162. Surowiak, P.; Drąg, M.; Materna, V.; Dietel, M.; Lage, H., Betulinic acid reveal stronger cytotoxic activity toward normal melanocyte cell line (NHEM-neo) than drug-resistant and drug-sensitive melanoma cell lines (MeWo). Mol. Med. Rep. 2009, 2, 543. 
      163. Szczuraszek, K.; Materna, V.; Halon, A.; Mazur, G.; Wróbel, T.; Kuliczkowski, K.; Maciejczyk, A.; Zabel, M.; Drąg, M.; Dietel, M.; Lage, H.; Surowiak, P., Positive correlation between cyclooxygenase-2 and ABC-transporter expression in non-Hodgkin Oncol. Rep. 2009, 22, 1315. 
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      165. Drąg-Zalesińska, M.; Kulbacka, J.; Saczko, J.; Wysocka, T.; Zabel, M.; Surowiak, P.; Drąg, M., Esters of betulin and betulinic acid with amino acids have improved water solubility and are selectively cytotoxic toward cancer cells. Bioorg. Med. Chem. Lett. 2009, 19, 4814. 
      166. Gajcy, K.; Librowski, T.; Lochyński, S., Concise synthesis of non-protein amino acid from natural product via Schmidt reaction Lett Org Chem 2009, 6, 186.
      167. Drąg, M.; Surowiak, P.; Drąg-Zalesinska, M.; Dietel, M.; Lage, H.; Oleksyszyn, J., Comparision of the cytotoxic effects of birch bark extract, betulin and betulinic acid towards human gastric carcinoma and pancreatic carcinoma drug-sensitive and drug-resistant cell lines. Molecules 2009, 14, 1639. 
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