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Department of Chemical Biology and Bioimaging

2018

Poreba M, Rut W, Vizovisek M, Groborz K, Kasperkiewicz P, Finlay D, Vuori K, Turk D, Turk B, Salvesen GS, Drag M, Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes Chemical Science 2018, 9, 2113.

Gonzalez-Ramirez ML*, Poreba M*, Snipas SJ, Groborz K, Drag M, Salvesen GS (* equal contribution), Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1 Journal of Biological Chemistry 2018, 293, 7058.

Serafin-Lewańczuk M, Klimek-Ochab M,Brzezińska-Rodak M, Żymańczyk-Duda E, Fungal synthesis of chiral phosphonic synthetic platform – Scope and limitations of the method Bioorganic Chemistry 2018, 77, 402.

Stach N, Kalinska M, Zdzalik M, Kitel R, Karim A, Serwin K, Rut W, Larsen K, Jabaiah A, Firlej M, Wladyka B, Daugherty P, Stennicke H, Drag M, Potempa J, Dubin G, Unique Substrate Specificity of SplE Serine Protease from Staphylococcus aureus Structure 2018, 26, 572.

Pieła A, Żymańczyk-Duda E, Brzezińska-Rodak M, Duda M, Grzesiak J, Klimek-Ochab M, Nanosilica synthesis mediated by Aspergillus parasiticus strain. Fungal Biology 2018, 1.

Poreba M, Kasperkiewicz P, Rut W, Drag M, Screening Combinatorial Peptide Libraries in Protease Inhibitor Drug Discovery Extracellular Targeting of Cell Signaling in Cancer: Strategies Directed at MET and RON Receptor Tyrosine Kinase Pathways, 1 2018, 1.

Piasta, K.; Dziełak, A.; Mucha, A.; Gumienna-Kontecka, E., Non-symmetrical bis(aminoalkyl)phosphinates: new ligands with enhanced binding of Cu(II) ions. New J. Chem. 2018, 42, 7737.

Gałęzowska, J.; Czapor-Irabek, H.; Chmielewska, E; Kafarski, P.; Janek, T., Aminobisphosphonates based on cyclohexane backbone as coordinating agents for metal ions. Thermodynamic, spectroscopic and biological studies New J. Chem. 2018, 42, 7723.

Gałęzowska, J.; Czapor-Irzabek, H.; Chmielewska, E.; Kafarski, P.; Janek, T., Aminobisphosphonates based on cyclohexane backbone as coordinating agents for metal ions. Thermodynamic, spectroscopic and biological studies New J. Chem. 2018, 42, 7723.

Rut W, Poreba M, Kasperkiewicz P, Snipas SJ, Drag M, Selective substrates and activity-based probes for imaging of the human constitutive 20S proteasome in cells and blood samples Journal of Medicinal Chemistry 2018, 61, 5222.

Ewelina Węglarz-Tomczak, Michał Talma, Mirosław Giurg, Hans V. Westerhoff, Robert Janowski and Artur Mucha, Neutral metalloaminopeptidases APN and MetAP2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs Oncotarget 2018, 9, 29365.

P. Kafarski, M. Talma, Recent advances in design of new urease inhibitors: A review J. Adv. Res. 2018, 13, 101.

Weronika Wanat, Michał Talma, Józef Hurek, Małgorzata Pawełczak, Paweł Kafarski, Substituted phosphonic analogues of phenylglycine as inhibitors of phenylalanine ammonia lyase from potatoes Biochimie 2018, 151, 119.

Gałęzowska, J.; Chmielewska, E., Thermodynamics of the interactions of aminobisphosphonates and their calcium complexes with bovine serum albumin Chemistry and Biodiversity 2018, 15, 1.

Węglarz-Tomczak, E.; Talma, M.; Giurg, M.; Westerhoff, H.V.; Janowsk, R.; Mucha, A. , Neutral metalloaminopeptidases APN and MetAP2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs. Oncotarget 2018, 9, 29365.

Drewniak, M.*; Węglarz-Tomczak, E*; Ożga, K.; Rudzińska-Szostak, E.; Macegoniuk, K.; Tomczak, J. M.; Bejger, M.; Rypniewski, W.; Berlicki, Ł. *contributed equally., Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics. Bioorg. Chem. 2018, 81, 356.

Makowicz, E.; Jasicka-Misiak, I.; Teper, D.; Kafarski, P., HPTLC Fingerprinting—Rapid Method for the Differentiation of Honeys of Different Botanical Origin Based on the Composition of the Lipophilic Fractions Molecules 2018, 23, 1.

Barry R, John SW, Liccardi G, Tenev T, Jaco J, Chen Ch, Choi J, Kasperkiewicz P, Fernandes-Alnemri T, Alnemri E, Drag M, Chen Y, Meier P, SUMO-mediated regulation of NLRP3 modulates inflammasome activity Nature Communications 2018, 9, 3001.

Vizovisek M, Vidmar R, Drag M, Fonovic M, Salvesen GS, Turk B, Protease Specificity: Towards In Vivo Imaging Applications and Biomarker Discovery Trends in Biochemical Sciences 2018, 1, 1.

Hałdys, K.; Goldeman, W.; Jewgiński, M.; Wolińska, E.; Anger, N.; Rossowska, J.; Latajka, R.;, Inhibitory properties of aromatic thiosemicarbazones on mushroom tyrosinase: Synthesis, kinetic studies, molecular docking and effectiveness in melanogenesis inhibition. Bioorg. Chem. 2018, 81, 577.

Malik-Gajewska, M.; Trynda, J.; Zierkiewicz, W.; Helios, K.; Latajka, R.; Wietrzyk, J.; Michalska, D., Picoplatin-based complexes with the bioactive orotate and 5-fluoroorotate ligands: Synthesis, DFT calculations, structure, spectroscopic characterization and in vitro cytotoxicity. J. Mol. Struct. 2018, 1171, 155.

Kracker, O.; Góra, J.; Krzciuk-Gula, J.; Marion, A.; Neumann, B.; Stammler, H-G.; Niess, A.; Antes, I.; Latajka, R.; Sewald, N., 1,5-Disubstituted 1,2,3-Triazole-Containing Peptidotriazolamers: Design Principles for a Class of Versatile Peptidomimetics. Chem. Eur. J. 2018, 24, 953.

Marion, A.; Gora, J.; Kracker, O.; Frohr, T.; Latajka, R.; Sewald, N.; Antes, I., Amber-Compatible Parametrization Procedure for Peptide-like Compounds: Application to 1,4- and 1,5-Substituted Triazole-Based Peptidomimetics. J. Chem. Inf. Model. 2018, 58, 90.

Ntatsopoulos, V.; Macegoniuk, K.; Mucha, A.; Vassiliou, S.; Berlicki, Ł., Structural exploration of cinnamate-based phosphonic acids as inhibitors of bacterial ureases. Eur. J. Med. Chem. 2018, 159, 307.

Sikorska E, Stachurski O, Neubauer D, Małuch I, Wyrzykowski D, Bauer M, Brzozowski K, Kamysz W, Short arginine-rich lipopeptides: from self-assembly to antimicrobial activity Biochimica et Biophysica Acta. Biomembranes 2018, 1860, 2242.

Świderska KW, Szlachcic A, Opaliński Ł, Zakrzewska M, Otlewski J, FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and ?-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1 International Journal of Molecular Sciences 2018, 19, 2098.

Makowicz, E.; Kafarski, P.; Jasicka-Misiak, I., Chromatographic fingerprint of the volatile fraction of rare Hedera helix honey and biomarkers identification Eur. Food Res. Technol. 2018, 244, 2169.

Nocek, B. P.; Khusnutdinova, A. N.; Ruszkowski, M.; Flick, R.; Burda, M.; Batyrova, K.; Brown, G.; Mucha, A.; Joachimiak, A.; Berlicki, Ł.; Yakunin, A. F., Structural insights into substrate selectivity and activity of bacterial polyphosphate kinases ACS Catal. 2018, 8, 10746.

Kasperkiewicz P, Kołt S, Janiszewski T, Groborz K, Poręba M, Snipas SJ, Salvesen GS, Drąg M, Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probes Scientific Reports 2018, 8, 15998.

Kozioł, A., Frątczak, J., Grela, E., Szczepanik, M., Gabryś, B., Dancewicz, K., Lochyński, S.,, Synthesis and biological activity of new derivatives with the preserved carane system Nat. Prod. Res., 2018, 1.

Kozioł, A.,Macegoniuk, K.M., Grela, E., Grabowiecka, A., Biernat, M., Lochyński, S., Synthesis of terpenoid oxo derivatives with antiureolytic activity Mol. Biol. Rep., 2018, 1.

Sokoła-Wysoczańska, E., Wysoczański, T., Wagner, J., Czyż, K., Bodkowski, R., Lochyński, S., Patkowska-Sokoła, B.,, Polyunsaturated fatty acids and their potential therapeutic role in cardiovascular system disorders - a review. Nutrients, 2018, 10, 1561.

Malek N, Starowicz K., Joint problems arising from lack of repair mechanisms: can cannabinoids help? British Journal of Pharmacology 2018, 1.

Korostynski M, Malek N, Piechota M, Starowicz K., Cell-type-specific gene expression patterns in the knee cartilage in an osteoarthritis rat model Functional & Integrative Genomics 2018, 18, 79.

Mlost J, Kostrzewa M, Malek N, Starowicz K, Molecular Understanding of the Activation of CB1 and Blockade of TRPV1 Receptors: Implications for Novel Treatment Strategies in Osteoarthritis International Journal of Molecular Sciences 2018, 19, 342.

Boratynski, P.J.; Galezowska, J.; Turkowiak, K.; Anisiewicz, A.; Kowalczyk, R .; Wietrzyk, J., Triazole Biheterocycles from Cinchona Alkaloids: Coordination and Antiproliferative Properties CHEMISTRYSELECT 2018, 3, 9368.

Dajek, M.; Kowalczyk, R.; Boratynski, P. J. , trans-1,2-Diaminocyclohexane-based sulfonamides as effective hydrogen-bonding organocatalysts for asymmetric Michael-hemiacetalization reaction Catalysis Science & Technology 2018, 8, 4358.

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